Mercury in drug and biologic products

Mercury in Drug and Biologic Products

Hoofdpagina
Stichting Amalgaamvrij Nederland

Mercury in Drug and Biologic Products

The information in this list is derived from submissions made by
manufacturers in response to the agency's call-for-data notices of
December 14, 1998 (63 FR 68775) and April 29, 1999 (64 FR 23083), the agency's Drug
Registration and Listing System, and other agency sources. Products
submitted in response to the call-for-data are preceded by an asterisk (*).
The mercury ingredients are abbreviated as TM for thimerosal, PMA for
phenylmercuric acetate, PMN for phenylmercuric nitrate, MA for mercuric
acetate, MN for mercuric nitrate, MB for merbromin, and MOY for mercuric
oxide yellow. The list includes nonhomeopathic human and veterinary drug
products and human biological products. Homeopathic drug products are
not included because of the low amounts of mercury present in the product.
The abbreviation NS under the % column means that the information was "not
stated" in the agency's Drug Registration and Listing System.

Mercury

   Manufacturer Name of Product Ingredient %
    Akorn Inc. AK Spore Ophthalmic Solution TM .001
    Akorn Inc. AK Spore HC Ophthalmic Combo Drops TM NS
    Akorn Inc. Fluoracaine Ophthalmic Solution TM NS
    Akorn Inc. AK Spore HC Otic Suspension TM NS
* Alcon Laboratories Profenal 1% Ophthalmic Solution TM .005
* Alcon Laboratories Adsorbonac 2% Ophthalmic Solution TM .004
* Alcon Laboratories Adsorbonac 5% Ophthalmic Solution TM .004
    ALK Laboratories Pharmacia Coccidioidin Vaccine TM .01
    Allergan Inc. Blephamide SOP Ophthalmic Ointment PMA .0008
    Allergan Inc. Bleph-10 Ophthalmic Ointment 10% PMA .0008
    Allergan Inc. FML SOP Ophthalmic Ointment 0.1% PMA .0008
    Allergan America Ocufen Ophthalmic Solution TM .005
    Allergan Inc. Poly Pred Ophthalmic Suspension TM .001
    Allergan America Poly Pred Ophthalmic Suspension TM .001
    Altaire Pharmaceuticals Nasal Relief 12 Hour Spray PMA NS
    American Assn. Retired Persons Oxymetazoline Nasal Spray PMA .002
    American International Chemical Thimerosal (bulk chemical) TM 100
    American International Chemical Thimerosal (bulk chemical) TM 100
    American International Chemical Thimerosal USP 97% (bulk chemical) TM 97
    American Pharmaceutical 12 Hour Nasal Solution PMA NS
    Appletree Markets Long Lasting Nasal Spray PMA NS
* B. F. Ascher & Co. Baby AYR Saline Nose Spray/Drops TM .00025
* B. F. Ascher & Co. AYR Saline Nasal Drops TM .00025
* B. F. Ascher & Co. AYR Saline Nasal Mist TM .00025
* Bausch & Lomb Flurbiprofen Sodium Ophthalmic Solution TM .005
· Bausch & Lomb Neomycin & Polymyxin B Sulfates &
· Gramicidin Ophthalmic Solution TM .001
* Bausch & Lomb Neomycin & Polymyxin B Sulfates &
Hydrocortisone Otic Suspension TM .01
* Bausch & Lomb Sulfacetamide Sodium & Prednisolone
Sodium Phosphate Ophthalmic Solution 10%/.23% TM .01
    Baxter Healthcare Corporation Immune Globulin Vaccine TM .01
* Bayer Corporation Nasal Saline Moisturizer Spray TM .001
* Bayer Corporation Neo-Synephrine 12-Hour Nasal Decongestant Spray PMA .002
* Bayer Corporation Neo-Synephrine Extra Strength Drops TM .001
* Bayer Corporation Neo-Synephrine Mild Formula Spray TM .001
* Bayer Corporation Neo-Synephrine Regular Strength Spray TM .001
* Bayer Corporation Neo-Synephrine Extra Strength Spray TM .001
* Bayer Corporation Neo-Synephrine Regular Strength Drops TM .001
* Bayer Corporation Neo-Synephrine 12-Hour Extra Moisturizing Spray PMA .002
* Berna Products Tetanus Vaccine Adsorbed TM .01
    Bioport Corporation Tetanus Toxoid Adsorbed TM .01
    Bioport Corporation Rabies Vaccine Adsorbed TM .01
    Bioport Corporation Immune Globulin (Human) TM 01
    Bioport Corporation Pertussis Vaccine Adsorbed TM .01
    Bioport Corporation Diphtheria & Tetanus Toxoids Adsorbed TM .01
    Bioport Corporation Diphtheria & Tetanus Toxoids & Pertussis Vaccine Adsorbed TM .01
* Bristol-Myers Squibb Fungizone Lotion TM .01
* Bristol-Myers Squibb Fungizone Cream TM .01
    C.O. Truxton Inc. Bio-Cot Otic Suspension TM .01
    C.O. Truxton Inc. Decongest Nasal Spray PMA NS
    Carlisle Laboratories Oxymetazoline Nasal Relief Spray PMA NS
    Carlisle Laboratories Neomycin Polymyxin B Sulfates Gramicidin Ophthalmic Solution TM .01
    Carlisle Laboratories Neomycin Polymyxin B Sulfates Hydrocortisone Otic Suspension TM .01
    Cheshire Pharmaceutical Otocort Otic Suspension TM .01
    Cheshire Pharmaceutical Ocutricin Ophthalmic Solution TM .01
    Cheshire Pharmaceutical Sulfapred Ophthalmic Solution TM NS
    Clay Park Labs. PREP Hemorrhoidal Ointment MN NS
    Clay Park Labs. Little Noses Saline Spray/Drops MA .002
    Clay Park Labs Cheracol Nasal Spray 12 Hour PMA .005
    Clay Park Labs PREP-HEM Hemorrhoidal Suppositories PMN NS
    Clay Park Labs Long Acting Nasal Spray PMA NS
    Conair Corp. Decongestant Nasal Spray PMA NS
* Connaught Laboratories Diphtheria & Tetanus Toxoids Adsorbed TM .01
* Connaught Laboratories Diphtheria & Tetanus Toxoids & Pertussis Vaccine Adsorbed TM .01
* Connaught Laboratories Mumps Skin Test Antigen TM .01
* Connaught Laboratories Influenza Virus Vaccine, Trivalent, Types A & B TM .01
* Connaught Laboratories Tetanus Toxoid for Booster Use Only TM .01
* Connaught Laboratories Influenza Virus Vaccine, Trivalent, Types A & B TM .01
* Connaught Laboratories Haemophilus b Conjugate Vaccine Reconstituted with
Diphtheria & Tetanus Toxoids & Acellular Pertussis Vaccine Adsorbed TM .01
* Connaught Laboratories Tetanus Toxoid Adsorbed TM .01
* Connaught Laboratories Diphtheria & Tetanus Toxoids & Acellular Pertussis
Vaccine Adsorbed TM .01
* Connaught Laboratories Haemophilus b Conjugate Vaccine TM .01
* Connaught Laboratories Tetanus and Diphtheria Toxoids Adsorbed TM .01
* Connaught Laboratories Japanese Encephalitis Virus Vaccine TM .007
* Connaught Laboratories Diluent for Meningococcal Vaccine Groups TM 0.1
    CVS Revco DS Inc. 12 Hour Decongestant Pump Nasal Spray PMA NS
    CVS Nasal Spray Pump PMA NS
    Darby Group Companies Neomycin Polymyxin B Sulfates Hydrocortisone Otic
Suspension TM .01
    Dolder Ltd. Thimerosal (bulk chemical) TM 100
    Dorex International Corp. Long Acting Nasal Spray PMA .002
    Drug Guild Distributors Long Acting Decongestant Nasal Spray PMA NS
    Drug Guild Distributors Nasal Spray 12 Hour Pump PMA NS
    Drug Guild Distributors Long Acting Nasal Spray Kolex LA PMA .002
    DRX Pharmaceutical Blephamide Ophthalmic Ointment PMA NS
    DRX Pharmaceutical Cortisporin Ophthalmic Suspension TM .001
    DRX Pharmaceutical Neomycin Polymyxin B Sulfates Hydrocortisone Ophthalmic Suspension TM NS
    DRX Pharmaceutical Neomycin Polymyxin B Hydrocortisone Otic Suspension TM .01
    DRX Pharmaceutical Neomycin Polymyxin B Gramicidin Ophthalmic Solution TM .01
    DRX Pharmaceutical Vasocidin Ophthalmic Solution TM NS
    DRX Pharmaceutical Colymycin S Otic Suspension TM .002
    DRX Pharmaceutical Pediotic Otic Suspension TM NS
    Dysers Sal Thimerosal (bulk chemical) TM NS
    Family Independent Pharmacy 12 Hour Nasal Decongestant Spray PMA NS
    Family Independent Pharmacy Long Acting Nasal Spray PMA NS
    Farm Fresh Inc. Hemorrhoid Relief Ointment PMN .01
    Fays Drug Services 12 Hour Nasal Spray Pump PMA NS
    Federated Foods Long Acting Nasal Spray PMA .002
    Fleming Companies 12 Hour Nasal Spray PMA .002
    Foxmeyer Drug Co. Nasal Spray Pump PMA NS
    Global Source Nasin Long Acting Nasal Spray PMA NS
    Harco Drug Mercurochrome Aqueous Solution MB 2
    Harris-Teeter Oxymetazoline Nasal Spray PMA .002
    Hi Tech Pharmacal Co. Long Acting Nasal Spray PMA .002
    Hudson Corp. Nasal Spray Extended Relief PMA NS
    Hurst Pharmaceutical Duomycin-HC Otic Suspension TM .01
    K and B Distributors Mercurochrome Aqueous Solution MB 2
* King Pharmaceuticals Cortisporin Ophthalmic Suspension TM .001
* King Pharmaceuticals Neosporin Ophthalmic Suspension TM .001
* King Pharmaceuticals Viroptic Ophthalmic Solution TM .001
    King Pharmaceuticals Neomycin Polymyxin B Sulfates Hydrocortisone Otic Suspension TM NS
* King Pharmaceuticals Pediotic Suspension TM .001
* King Pharmaceuticals Cortisporin Otic Suspension TM .01
    Kinray Oxymetazoline Nasal Spray PMA .002
    Laboratori Derivati Adrenal Cortex Injection TM .01
    Leader 12 Hour Nasal Spray PMA NS
    Leader Nasal Pump Spray PMA NS
    Longs Drug Stores Nasal Spray Pump PMA NS
    LS Raw Materials Ltd. Mercurochrome NF 12 100% (bulk chemical) MB 100
    Major Pharmaceuticals Cortomycin Ophthalmic Suspension TM NS
    Major Pharmaceuticals Sulfacetamide Sodium & Prednisolone Sodium
Phosphate Ophthalmic Solution TM .01
    Major Pharmaceuticals Cortomycin Otic Suspension TM .01
    Major Pharmaceuticals Neocidin Ophthalmic Solution TM .01
    Martin Surgical Supply Testosterone Injection Suspension 50 mg TM .008
    Martin Surgical Supply Testosterone Injection Suspension 100 mg TM NS
* Massachusetts Public Health Biologic Labs
Tetanus and Diphtheria Toxoids Adsorbed For Adult Use TM .003
* Massachusetts Public Health Biologic Labs
Diphtheria and Tetanus Toxoids Adsorbed TM .01
    Mays Drug Stores Hemorrhoid Relief Ointment PMN .01
    Medalist Laboratories Long Lasting Nasal Spray Pump PMA NS
* Medeva Pharmaceuticals Influenza Virus Vaccine TM .01
* Merck & Co. Hepatitis B Vaccine, recombinant TM .005
* Merck & Co. Antivenin (Lactrodectus Mactans) TM .01
    Meyers Supply Inc. Long Acting Nasal Spray PMA .002
    Naska Pharmacal Co. Hemorrhoid Relief Ointment PMN .01
    Navresso Long Acting Nasal Spray PMA NS
    North American Vaccine Diphtheria & Tetanus Toxoids & Pertussis Adsorbed TM .01
    Omicron Quimica SA Thimerosal USP 97% (bulk chemical) TM 97
* Ortho-Clinical Diagnostics Rho (D) Immune Globulin (Human) TM .003
* Ortho-Clinical Diagnostics Rho (D) Immune Globulin (Human) TM .003
    Parade (Grocer's Supply) Oxymetazoline Nasal Spray PMA .002
    Parke Davis Elase-Chloromycetin Topical Ointment TM NS
* Parkedale Pharmaceuticals Coly-Mycin S Otic Suspension TM .002
* Parkedale Pharmaceuticals Influenza Virus Vaccine, Trivalent, Types A & B TM .01
    Pay N Save Corp. Decongestant Nasal Spray PMA NS
    Pharmacia & Upjohn Anti-Thymocyte Immune Globulin, Human TM .01
    Pharmacia & Upjohn Allergen Patch Test TM 2
    Pharmedix Bleph 10 Ophthalmic Solution 10% TM .005
    Pharmedix Viroptic Ophthalmic Solution 1% TM .001
    Pharmedix Blephamide Ophthalmic Ointment PMA NS
    Pharmedix Triple Antibiotic Ophthalmic Solution TM .01
    Pharmedix Colymycin S Otic Solution TM .002
    Pharmedix Neo Poly with HC Otic Suspension TM .01
    Physicians Total Care NeoSynephrine Nasal Spray 0.25% TM NS
    Physicians Total Care Inc. Neomycin Polymyxin B Sulfates
Hydrocortisone Ophthalmic Suspension TM NS
    Physicians Total Care Inc. Viroptic Ophthalmic Solution TM .001
    Physicians Total Care Inc. Cortisporin Ophthalmic Suspension TM .001
    Physicians Total Care Inc. Ocufen Ophthalmic Solution TM .0005
    Physicians Total Care Inc. Vasocidin Ophthalmic Solution TM NS
    Ping On Ointment Co. Ltd. Ping On Topical Ointment Mercury NS
    Prime Natural Health 12 Hour Nasal Spray PMA NS
    Primedics Laboratories Testerone Injection Suspension 50 mg TM .008
    Publix Supermarkets Long Acting Decongestant Nasal Spray PMA NS
    Publix Inc. Long Acting Nasal Spray PMA NS
    Qualitest Pharmaceuticals Nasal Spray Solution PMA NS
    Qualitest Pharmaceuticals Antibiotic HC Otic Suspension TM NS
    RDS Acquisition Corp. 12 Hour Nasal Spray PMA NS
    Republic Drug Co. 12 Hour Nasal Spray PMA .002
    Rugby Laboratories Nasal Relief Spray Long Acting PMA .002
    Schein Pharmaceutical Neomycin Polymyxin B Sulfates Hydrocortisone
Ophthalmic Suspension TM NS
    Schein Pharmaceutical Sulfacetamide Sodium & Prednisolone Sodium
Phosphate Ophthalmic Solution TM NS
    Schein Pharmaceutical Testosterone Injection Suspension 100 mg TM NS
    Schein Pharmaceutical Neomycin Polymyxin B Sulfates Hydrocortisone
Otic Suspension TM .01
    Schein Pharmaceutical Trifluridine Ophthalmic Solution TM NS
    Schein Pharmaceutical Oxymetazoline HC1 Nasal Spray PMA NS
    Schein Pharmaceutical Phenylephrine HC1 Nasal Solution 1% TM NS
* Schering-Plough Animal Health Gentocin Durafilm Ophthalmic Solution
(for dogs only) PMN .002
    Scrivner, Inc. Hemorrhoid Relief Ointment PMN .01
    Sight Pharmaceuticals Neomycin Polymyxin B Sulfates Hydrocortisone
Otic Suspension TM NS
    Sight Pharmaceuticals Sulfacetamide Sodium & Prednisolone Sodium
Phosphate Ophthalmic Solution TM .01
* SmithKline Beecham Hepatitis B Vaccine, recombinant TM .005
    Spectrum Quality Products Merbromin (bulk chemical) MB 100
    Spectrum Quality Products Mercuric Oxide Yellow (bulk chemical) MOY 100
    Spectrum Quality Products Thimerosal (bulk chemical) TM 100
    Spectrum Quality Products Thimerosal (bulk chemical) TM 100
    Super Laboratories Long Acting Nasal Spray PMA NS
    Super D Drugs Long Acting Nasal Spray PMA NS
* Taro Pharmaceuticals Taro Nasal Decongestant Spray PMA .002
    Teral Laboratories Oticin HC Otic Suspension TM .01
    Thames Pharmacal Co. 12 Hour Nasal Spray PMA NS
    Thrift Drugs Long Acting Nasal Spray PMA NS
    Thrifty Payless Inc. Nasal Spray Pump Formula PMA NS
    Thrifty Payless Inc. Decongestant Nasal Spray Pump PMA NS
    United Research Labs Antibiotic Ear Suspension TM .01
    United Research Labs Neomycin Polymyxin B Sulfates Gramicidin
Ophthalmic Solution TM .01
    US Ophthalmics Fluorescein Sodium Ophthalmic Solution TM NS
    US Ophthalmics Sulf-10 Ophthalmic Solution TM NS
    US Ophthalmics Vasocidin Ophthalmic Solution TM NS
    US Ophthalmics Phenylephrine HC1 Ophthalmic Solution 10% TM NS
    USCO Logistics Procofen Ophthalmic Solution TM .005
    USCO Logistics Profenal Ophthalmic Solution TM .005
    VEDCO Inc. Tribiotic Ophthalmic Solution TM NS
    Waldbaum Inc. Hemorrhoidal Ointment MN NS
    Weeks and Leo Co. Inc. Long Acting Nasal Spray Solution PMA .002
* Whilehall-Robins Dristan 12-Hour Nasal Spray TM .002
* Wyeth Laboratories Antivenin (Micrurus Fulvius) TM .005
* Wyeth Laboratories Normal Horse Serum (1:10 dilution) TM .005
* Wyeth Laboratories Influenza Virus Vaccine, Trivalent, Types A & B TM .01
* Wyeth Laboratories Diphtheria and Tetanus Toxoids Adsorbed TM .01
* Wyeth Laboratories Antivenin (crotalidae) Polyvalent TM .005
* Wyeth Laboratories Tetanus and Diphtheria Toxoids Adsorbed TM .01
* Wyeth Laboratories Tetanus Toxoid, fluid TM .01
* Wyeth Laboratories Tetanus Toxoid Adsorbed TM .01
* Wyeth Laboratories Wydase Lyophilized Solution TM .01
* Wyeth Laboratories Wydase Solution Stabilized TM .01
* Wyeth Laboratories Bacteriostatic Water for Injection PMN .001
* Wyeth-Lederle Vaccines Diphtheria and Tetanus Toxoids & Acellular
Pertussis Vaccine Adsorbed TM .01
* Wyeth-Lederle Vaccines Pneumococcal Vaccine, Polyvalent TM .01
* Wyeth-Lederle Vaccines Diphtheria and Tetanus Toxoids & Pertussis
Vaccine Adsorbed & Haemophilus b

Conjugate Vaccine TM .01
* Wyeth-Lederle Vaccines Tetanus Toxoid Adsorbed TM .01
* Wyeth-Lederle Vaccines Tetanus and Diphtheria Toxoids Adsorbed TM .01
* Wyeth-Lederle Vaccines Diphtheria and Tetanus Toxoids Adsorbed TM .01
* Wyeth-Lederle Vaccines Haemophilus b Conjugate Vaccine TM .01
--------------------------------------------------------------------------------
FDA/Center for Drug Evaluation and Research
Last Updated:November 17, 1999
Originator: OTCOM/DML
HTML by PKS

-----Original Message-----
From: Sharon [mailto:starshar@bee.net]
Sent: Monday, April 09, 2001 8:07 PM
To: oxyplus@yahoogroups.com
Subject: [oxyplus] Mercury fillings linked to Alzheimer's

SCIENTISTS CONNECT ALZHEIMER'S DISEASE TO MERCURY

International Academy of Oral Medicine and Toxicology
P.O. Box 608531
Orlando
FL 32860-8531
Phone: 407-298-2450
Fax: 407-298-3075
Email: mziff@iaomt.org *
Internet: http://www.iaomt.org

NEW RESEARCH CONNECTS MERCURY TO ALZHEIMER'S DISEASE!

Research conducted at the University of Calgary Faculty of Medicine has
demonstrated that trace amounts of mercury can cause the type of damage
to nerves that is characteristic of the damage found in Alzheimer's
Disease.
The level of mercury exposure is consistent with those levels found in
humans with mercury/silver amalgam dental fillings. The exposure to
mercury caused the formation of "neurofibrillar tangles," which are one of the
two diagnostic markers for Alzheimer's Disease. The scientists found that
other metals, including aluminum, did not cause the damage. Previous research
has shown that mercury can cause the formation of the other Alzheimer's
Disease diagnostic marker, "amyloid plaques."

The research, published in a peer-reviewed medical journal, is
accompanied by a video visual presentation of the effect. Utilizing digital
time-lapse photography, this video shows rapid damage to the nerve cells after
introduction of minute amounts of mercury. Funding for this video was
provided by the International Academy of Oral Medicine and Toxicology
(IAOMT).

SPECIAL NOTE: The University of Calgary has placed a copy of the video
on
their site at:

http://movies.commons.ucalgary.ca/mercury/

To view the video you will need "Quick Time" Player which can be
dowloaded from the site if you do not have it.

This video will be available to media contacts (only) through:

Miss Karen Thomas
Media Relations
University of Calgary, Faculty of Medicine
T: 403-220-2945
F: 403-210-8141
Email: thomask@ucalgary.ca

Media Embargo Date: 26 March 2001
Title: "Retrograde Degeneration of Neurite Membrane
Structural Integrity of Nerve Growth Cones Following In
Vitro Exposure To mercury."
Authors: Leong, CW; Syed, NI; Lorscheider, FL.
Journal: NeuroReport, 12(4):733-737, 2001.

BIOPROBE COMMENT: This study should remove all doubt regarding the role
that dental mercury from amalgam fillings plays in the development of
Alzheimer's Disease (AD). Although the American Dental Association would like to
have you believe otherwise, science has clearly demonstrated that there is a
positive correlation between brain mercury levels and the number and
surfaces of "mercury/silver" amalgam dental fillings. The mercury levels
that caused the devastating damage to nerve cells in the above referenced
study were 100 to 1000 times below those found in the brains of people
with "mercury/silver" amalgam dental fillings.

In 1997, researchers at the University of Calgary Medical School and the
College of Pharmacy at the University of Kentucky clearly demonstrated
that exposing rats to the same levels of mercury vapor that can be released
from "mercury/silver" amalgam dental fillings caused the mercury to interact
with brain tubulin and disassemble microtubles that maintain neurite
structure.
The identical neurochemical lesion of similar or greater magnitude is
evident in Alzheimer brain homogenates from approximately 80% of
patients, when compared to human age-matched neurological controls.
(Neurotoxicology 1997;18(2):315-324)

In 2000, researchers at the Neurobiology Laboratory, Psychiatric
University Hospital in Basel, Switzerland using neuroblastoma cells exposed to
mercury demonstrated an increase in production of amyloid protein that makes up
the amyloid plaques as well as significantly increasing the phophorylation
of Tau protein. (J Neurochem 2000 Jan;74(1):231- 236)

Studies demonstrating a correlation between amalgam dental fillings and
brain mercury levels:

Lakartidningen 1986 Feb 12;83(7):519-522
Swedish Dental Journal 1987;11(5):179-187
Sci Total Environ 1987 Oct;66:263-268
J Prosthet Dent 1987 Dec:58(6):704-707
FASEB J 1989 Dec;3(14):2651-2646
Sci Total Environ 1990 Dec 1;99(1-2):1-22
Sci Total Environ 1993 Sep 30;138(1-3):101-115
J Trace Elem Med Biol 1995 Jul;9(2):82-87
Zentralbl Hyg U:mweltmed 1996 Feb;198(3):275-291
FASEB J 1998 Aug;12(11):971-980
Biometals 1999 Sep;12(3):227-231

THERE IS NO MEDICAL ADVICE HERE!

This list is the 1st Amendment in action. The things you will find here
are for information and research purposes only. We are people sharing
information we believe in. If you act on ideas found here, you do so at
your own risk. Self-help requires intelligence, common sense, and the
ability to take responsibility for your own actions. By joining the list you agree
to hold yourself FULLY responsible FOR yourself. Do not use any ideas
found here without consulting a medical professional, unless you are a
researcher or health care provider

Stichting Amalgaamvrij Nederland
Hoofdpagina